Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etodolac
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Etodolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir and emtricitabine are cleared by the kidney, and cobicistat raises serum creatinine by inhibiting tubular secretion. NSAIDs such as etodolac can reduce renal perfusion, and use with tenofovir-containing regimens has been linked to kidney injury.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from NSAID-induced reduction in renal blood flow and competing renal elimination pathways of tenofovir and emtricitabine.
What to do
Avoid etodolac and use alternative analgesics such as paracetamol where possible. If an NSAID is needed, use the lowest dose briefly and monitor serum creatinine, phosphate and urinary protein.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Etodolac?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenofovir and emtricitabine are cleared by the kidney, and cobicistat raises serum creatinine by inhibiting tubular secretion. NSAIDs such as etodolac can reduce renal perfusion, and use with tenofovir-containing regimens has been linked to kidney injury.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid etodolac and use alternative analgesics such as paracetamol where possible. If an NSAID is needed, use the lowest dose briefly and monitor serum creatinine, phosphate and urinary protein.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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