Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Flutamide
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Flutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and CYP1A2 is the main pathway for flutamide, so exposure changes are uncertain. Flutamide is hepatotoxic, and any increase in exposure could raise liver injury risk.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible reduction of flutamide metabolism through cobicistat CYP3A4 inhibition, though the clinical contribution is not well established.
What to do
Monitor liver function tests regularly and watch for signs of hepatotoxicity; consider an alternative antiandrogen if abnormalities appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elvitegravir / cobicistat / emtricitabine / tenofovir df and Flutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Flutamide
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Flutamide?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and CYP1A2 is the main pathway for flutamide, so exposure changes are uncertain. Flutamide is hepatotoxic, and any increase in exposure could raise liver injury risk.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly and watch for signs of hepatotoxicity; consider an alternative antiandrogen if abnormalities appear.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
