Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-vilanterol
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and can raise exposure to inhaled fluticasone furoate and vilanterol. Systemic corticosteroid effects, including Cushing syndrome and adrenal suppression, and beta-agonist cardiovascular effects may occur.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP3A4-mediated metabolism of fluticasone furoate and vilanterol.
What to do
Monitor for corticosteroid excess and beta-agonist effects such as tachycardia and hypokalemia. Consider switching to beclometasone if long-term use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and can raise exposure to inhaled fluticasone furoate and vilanterol. Systemic corticosteroid effects, including Cushing syndrome and adrenal suppression, and beta-agonist cardiovascular effects may occur.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess and beta-agonist effects such as tachycardia and hypokalemia. Consider switching to beclometasone if long-term use is needed.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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