Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Glimepiride
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glimepiride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir may modestly induce CYP2C9, while cobicistat inhibits CYP3A4 and other pathways. The net effect on glimepiride is uncertain but could include reduced glycemic control.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2C9 induction by elvitegravir increasing glimepiride metabolism; net effect uncertain.
What to do
Monitor blood glucose after starting or stopping this regimen. Adjust the glimepiride dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Glimepiride?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elvitegravir may modestly induce CYP2C9, while cobicistat inhibits CYP3A4 and other pathways. The net effect on glimepiride is uncertain but could include reduced glycemic control.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glimepiride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping this regimen. Adjust the glimepiride dose if control changes.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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