Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Glyburide
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glyburide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir may induce CYP2C9 modestly, while cobicistat inhibits CYP3A4 and some transporters, so the net effect on glyburide exposure is uncertain. Glycemic control could change in either direction.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on glyburide clearance: possible CYP2C9 induction by elvitegravir and CYP3A4 and transporter inhibition by cobicistat.
What to do
Monitor blood glucose after starting or stopping the regimen and adjust the glyburide dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Glyburide?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elvitegravir may induce CYP2C9 modestly, while cobicistat inhibits CYP3A4 and some transporters, so the net effect on glyburide exposure is uncertain. Glycemic control could change in either direction.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Glyburide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping the regimen and adjust the glyburide dose according to response.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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