Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Hydrochlorothiazide-losartan
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and may alter conversion of losartan to its active metabolite, so antihypertensive effect may change unpredictably. Tenofovir with a thiazide and an ARB may also add to renal risk in volume-depleted patients.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4 and elvitegravir may induce CYP2C9, altering losartan metabolism and activation.
What to do
Monitor blood pressure and adjust the losartan dose as needed. Monitor renal function and potassium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and may alter conversion of losartan to its active metabolite, so antihypertensive effect may change unpredictably. Tenofovir with a thiazide and an ARB may also add to renal risk in volume-depleted patients.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adjust the losartan dose as needed. Monitor renal function and potassium periodically.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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