Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Imatinib
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and can raise imatinib concentrations, increasing fluid retention, myelosuppression, hepatotoxicity and other adverse effects. Imatinib itself may modestly affect cobicistat-boosted exposure. The interaction is manageable rather than an absolute contraindication.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing imatinib metabolism and increasing its levels.
What to do
Monitor blood counts, liver enzymes, and fluid status, and consider reducing the imatinib dose if toxicity develops. Consider an alternative antiretroviral regimen without a booster.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Imatinib?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and can raise imatinib concentrations, increasing fluid retention, myelosuppression, hepatotoxicity and other adverse effects. Imatinib itself may modestly affect cobicistat-boosted exposure. The interaction is manageable rather than an absolute contraindication.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver enzymes, and fluid status, and consider reducing the imatinib dose if toxicity develops. Consider an alternative antiretroviral regimen without a booster.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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