Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Indomethacin
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Indomethacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is renally eliminated and associated with kidney toxicity, and NSAIDs can reduce renal perfusion. Concurrent use, especially at high or repeated NSAID doses, raises the risk of acute kidney injury.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity: NSAID-induced reduction in renal blood flow plus tenofovir proximal tubular toxicity, with competition for tubular secretion.
What to do
Prefer a non-NSAID analgesic; if an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Indomethacin?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenofovir is renally eliminated and associated with kidney toxicity, and NSAIDs can reduce renal perfusion. Concurrent use, especially at high or repeated NSAID doses, raises the risk of acute kidney injury.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Indomethacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic; if an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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