Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Ketoprofen
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is eliminated by the kidney, and NSAIDs can reduce renal perfusion and compete for tubular secretion. This may raise tenofovir exposure and increase the risk of renal tubular injury and kidney impairment.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal perfusion plus competition for renal tubular secretion raises tenofovir and emtricitabine exposure.
What to do
Prefer non-NSAID analgesics such as paracetamol; if ketoprofen is necessary, use the lowest dose briefly and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Ketoprofen?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is eliminated by the kidney, and NSAIDs can reduce renal perfusion and compete for tubular secretion. This may raise tenofovir exposure and increase the risk of renal tubular injury and kidney impairment.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer non-NSAID analgesics such as paracetamol; if ketoprofen is necessary, use the lowest dose briefly and monitor serum creatinine and phosphate.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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