Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Maprotiline
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP2D6 and CYP3A4, which can raise maprotiline concentrations. Higher exposure increases the risk of anticholinergic effects, sedation, seizures and cardiac conduction abnormalities.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP2D6-mediated maprotiline metabolism.
What to do
Start maprotiline at a low dose and titrate based on response and tolerability. Monitor ECG and for anticholinergic or CNS toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Maprotiline?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP2D6 and CYP3A4, which can raise maprotiline concentrations. Higher exposure increases the risk of anticholinergic effects, sedation, seizures and cardiac conduction abnormalities.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start maprotiline at a low dose and titrate based on response and tolerability. Monitor ECG and for anticholinergic or CNS toxicity.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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