Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Metaxalone
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and other CYP enzymes involved in metaxalone clearance, which may increase metaxalone exposure. This could cause more drowsiness, dizziness and CNS depression.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP enzymes (mainly CYP3A4) that metabolize metaxalone.
What to do
Monitor for excessive sedation and dizziness, and consider a lower metaxalone dose or an alternative muscle relaxant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Metaxalone?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and other CYP enzymes involved in metaxalone clearance, which may increase metaxalone exposure. This could cause more drowsiness, dizziness and CNS depression.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness, and consider a lower metaxalone dose or an alternative muscle relaxant.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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