Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Nicardipine
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and can raise nicardipine concentrations. This may cause hypotension, flushing, headache and reflex tachycardia.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP3A4-mediated metabolism of nicardipine.
What to do
Monitor blood pressure and heart rate and titrate nicardipine carefully, using a lower starting dose. Adjust or switch if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Nicardipine?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and can raise nicardipine concentrations. This may cause hypotension, flushing, headache and reflex tachycardia.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate nicardipine carefully, using a lower starting dose. Adjust or switch if hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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