Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Oxaprozin
Severity: Major
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Oxaprozin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is eliminated by the kidney and is nephrotoxic, and NSAIDs reduce renal perfusion. Concurrent use raises the risk of acute kidney injury and tenofovir-related renal tubular toxicity, particularly with high or repeated NSAID doses.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAID-induced reduction in renal perfusion combined with tenofovir tubular toxicity and shared renal elimination; cobicistat also raises serum creatinine by inhibiting tubular secretion.
What to do
Use paracetamol or another non-NSAID analgesic when possible. If an NSAID is needed, use the lowest dose for the shortest time and monitor creatinine and phosphate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Oxaprozin?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenofovir is eliminated by the kidney and is nephrotoxic, and NSAIDs reduce renal perfusion. Concurrent use raises the risk of acute kidney injury and tenofovir-related renal tubular toxicity, particularly with high or repeated NSAID doses.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use paracetamol or another non-NSAID analgesic when possible. If an NSAID is needed, use the lowest dose for the shortest time and monitor creatinine and phosphate.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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