Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Repaglinide
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4, which contributes to repaglinide metabolism, so repaglinide exposure may rise and cause hypoglycemia. The effect is likely moderate since CYP2C8 is the main pathway. It is not a labeled contraindication.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP3A4 (and possibly OATP1B1) reduces repaglinide clearance.
What to do
Monitor blood glucose closely and consider a lower repaglinide dose, or choose another agent if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Repaglinide?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4, which contributes to repaglinide metabolism, so repaglinide exposure may rise and cause hypoglycemia. The effect is likely moderate since CYP2C8 is the main pathway. It is not a labeled contraindication.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider a lower repaglinide dose, or choose another agent if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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