Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sertraline
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and CYP2D6, and sertraline is metabolized by several CYPs including 2B6, 2C19, 2D6 and 3A4. Sertraline exposure may increase, with more adverse effects such as nausea, tremor and serotonergic symptoms.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP2D6 and CYP3A4, reducing sertraline clearance.
What to do
Titrate sertraline cautiously according to clinical response and monitor for dose-related adverse effects. Reduce the dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Sertraline?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and CYP2D6, and sertraline is metabolized by several CYPs including 2B6, 2C19, 2D6 and 3A4. Sertraline exposure may increase, with more adverse effects such as nausea, tremor and serotonergic symptoms.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sertraline cautiously according to clinical response and monitor for dose-related adverse effects. Reduce the dose if toxicity occurs.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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