Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Terbinafine
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cobicistat component strongly inhibits CYP3A4 and may modestly raise terbinafine exposure. The effect is expected to be small because CYP3A4 is a minor route for terbinafine.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cobicistat inhibits CYP3A4, a minor pathway of terbinafine metabolism.
What to do
No empirical dose change is needed. Monitor for terbinafine adverse effects and liver tests if therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Terbinafine?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The cobicistat component strongly inhibits CYP3A4 and may modestly raise terbinafine exposure. The effect is expected to be small because CYP3A4 is a minor route for terbinafine.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for terbinafine adverse effects and liver tests if therapy is prolonged.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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