Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Thioridazine
Severity: Contraindicated
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cobicistat component inhibits CYP2D6 and CYP3A, which can raise thioridazine concentrations. Elevated levels carry a risk of QTc prolongation, torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cobicistat inhibits CYP2D6 and CYP3A4, reducing thioridazine clearance.
What to do
Do not coadminister; use an alternative antipsychotic or alternative antiretroviral regimen. If exposure occurs, check ECG and electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elvitegravir / cobicistat / emtricitabine / tenofovir df and Thioridazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Thioridazine?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The cobicistat component inhibits CYP2D6 and CYP3A, which can raise thioridazine concentrations. Elevated levels carry a risk of QTc prolongation, torsades de pointes and sudden cardiac death.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antipsychotic or alternative antiretroviral regimen. If exposure occurs, check ECG and electrolytes.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
