Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Tinidazole
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and may increase tinidazole concentrations, which could raise the risk of tinidazole adverse effects such as nausea, metallic taste and neurological symptoms. The clinical consequences are probably modest and tinidazole is typically given as a short course.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP3A4-mediated tinidazole metabolism.
What to do
Coadministration is generally acceptable for a short tinidazole course; monitor for gastrointestinal and neurological adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Tinidazole?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and may increase tinidazole concentrations, which could raise the risk of tinidazole adverse effects such as nausea, metallic taste and neurological symptoms. The clinical consequences are probably modest and tinidazole is typically given as a short course.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration is generally acceptable for a short tinidazole course; monitor for gastrointestinal and neurological adverse effects.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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