Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Tolbutamide
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir may induce CYP2C9, which could lower tolbutamide concentrations, while cobicistat inhibits other CYPs. The net effect on glycemic control is uncertain, and reduced tolbutamide efficacy is possible.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2C9 induction by elvitegravir increasing tolbutamide clearance.
What to do
Monitor blood glucose after starting or stopping the regimen. Increase the tolbutamide dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Tolbutamide?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elvitegravir may induce CYP2C9, which could lower tolbutamide concentrations, while cobicistat inhibits other CYPs. The net effect on glycemic control is uncertain, and reduced tolbutamide efficacy is possible.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping the regimen. Increase the tolbutamide dose if control worsens.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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