Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Vancomycin
Severity: Moderate
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous vancomycin and the tenofovir disoproxil-containing combination can each injure the kidney. Used together they raise the likelihood of acute kidney injury, and cobicistat may further increase serum creatinine by inhibiting tubular secretion.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from vancomycin tubular injury and tenofovir proximal tubule toxicity.
What to do
Monitor serum creatinine, estimated creatinine clearance and urine protein or glucose at baseline and regularly during the vancomycin course. Check vancomycin levels and stop the regimen if renal function declines significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elvitegravir / cobicistat / emtricitabine / tenofovir df and Vancomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Vancomycin?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous vancomycin and the tenofovir disoproxil-containing combination can each injure the kidney. Used together they raise the likelihood of acute kidney injury, and cobicistat may further increase serum creatinine by inhibiting tubular secretion.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, estimated creatinine clearance and urine protein or glucose at baseline and regularly during the vancomycin course. Check vancomycin levels and stop the regimen if renal function declines significantly.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
