Drug interactions
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zafirlukast
Severity: Minor
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elvitegravir may induce CYP2C9 while cobicistat inhibits CYP3A4 and some other enzymes, so zafirlukast exposure could change in either direction. The net effect is unpredictable and not well characterized.
What this interaction means in plain words
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mixed enzyme effects of elvitegravir (weak CYP2C9 induction) and cobicistat (CYP3A4 inhibition) on zafirlukast metabolism.
What to do
No routine adjustment is needed; monitor asthma control and zafirlukast tolerability, including liver symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Zafirlukast?
MediHelp rates the interaction as minor. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elvitegravir may induce CYP2C9 while cobicistat inhibits CYP3A4 and some other enzymes, so zafirlukast exposure could change in either direction. The net effect is unpredictable and not well characterized.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor asthma control and zafirlukast tolerability, including liver symptoms.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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