Drug interactions
Empagliflozin-linagliptin + Glyburide
Severity: Moderate
Empagliflozin-linagliptin and Glyburide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide combined with linagliptin and empagliflozin increases the likelihood of hypoglycemia, which can be prolonged with glyburide especially in older adults or those with renal impairment.
What this interaction means in plain words
Empagliflozin-linagliptin and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Glyburide belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin secretagogue plus DPP-4 and SGLT2 inhibition.
What to do
Consider reducing the glyburide dose when initiating the combination and monitor glucose closely. Consider a lower-risk sulfonylurea in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Glyburide?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glyburide combined with linagliptin and empagliflozin increases the likelihood of hypoglycemia, which can be prolonged with glyburide especially in older adults or those with renal impairment.
How serious is the interaction between Empagliflozin-linagliptin and Glyburide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when initiating the combination and monitor glucose closely. Consider a lower-risk sulfonylurea in older patients.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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