Drug interactions
Empagliflozin-linagliptin + Mifepristone
Severity: Minor
Empagliflozin-linagliptin and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may modestly raise linagliptin concentrations. Because linagliptin is eliminated mostly unchanged and has a wide safety margin, a significant clinical effect is unlikely.
What this interaction means in plain words
Empagliflozin-linagliptin and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-linagliptin belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 may reduce linagliptin metabolism.
What to do
No dose change is normally needed. Follow glucose control as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Empagliflozin-linagliptin with Mifepristone?
MediHelp rates the interaction as minor. Empagliflozin-linagliptin and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4 and may modestly raise linagliptin concentrations. Because linagliptin is eliminated mostly unchanged and has a wide safety margin, a significant clinical effect is unlikely.
How serious is the interaction between Empagliflozin-linagliptin and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Follow glucose control as usual.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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