Drug interactions
Empagliflozin-linagliptin + Mitotane
Severity: Moderate
Empagliflozin-linagliptin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can lower linagliptin concentrations, which may reduce glycemic control. The effect is expected to persist for weeks after mitotane is stopped because of its long half-life.
What this interaction means in plain words
Empagliflozin-linagliptin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 (and possibly P-gp) by mitotane increases linagliptin clearance.
What to do
Monitor glucose control closely and consider an alternative antidiabetic agent if control is lost. Continue monitoring after mitotane discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Mitotane?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can lower linagliptin concentrations, which may reduce glycemic control. The effect is expected to persist for weeks after mitotane is stopped because of its long half-life.
How serious is the interaction between Empagliflozin-linagliptin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control closely and consider an alternative antidiabetic agent if control is lost. Continue monitoring after mitotane discontinuation.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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