Drug interactions
Empagliflozin-linagliptin + Prednisone
Severity: Moderate
Empagliflozin-linagliptin and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone raises blood glucose through insulin resistance and increased hepatic glucose output, opposing the effect of empagliflozin and linagliptin. Hyperglycemia may occur, especially with higher doses.
What this interaction means in plain words
Empagliflozin-linagliptin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Prednisone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism by glucocorticoid-induced insulin resistance and gluconeogenesis.
What to do
Monitor blood glucose more often during steroid courses and adjust antidiabetic therapy as needed. Reassess when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Prednisone?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone raises blood glucose through insulin resistance and increased hepatic glucose output, opposing the effect of empagliflozin and linagliptin. Hyperglycemia may occur, especially with higher doses.
How serious is the interaction between Empagliflozin-linagliptin and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during steroid courses and adjust antidiabetic therapy as needed. Reassess when the steroid is tapered.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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