Drug interactions
Empagliflozin-linagliptin + Repaglinide
Severity: Moderate
Empagliflozin-linagliptin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide promotes insulin secretion, and empagliflozin lowers glucose by a separate renal mechanism, so combining them can raise the chance of hypoglycemia. The risk is generally modest but real, especially with poor food intake.
What this interaction means in plain words
Empagliflozin-linagliptin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive glucose-lowering pharmacodynamic effects of an insulin secretagogue and an SGLT2 inhibitor.
What to do
Monitor blood glucose after starting the combination and reduce the repaglinide dose if hypoglycemia occurs. Advise patients to take repaglinide only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Empagliflozin-linagliptin with Repaglinide?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide promotes insulin secretion, and empagliflozin lowers glucose by a separate renal mechanism, so combining them can raise the chance of hypoglycemia. The risk is generally modest but real, especially with poor food intake.
How serious is the interaction between Empagliflozin-linagliptin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting the combination and reduce the repaglinide dose if hypoglycemia occurs. Advise patients to take repaglinide only with meals.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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