Drug interactions
Empagliflozin-linagliptin + Sarecycline
Severity: Minor
Empagliflozin-linagliptin and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a weak P-gp inhibitor and could marginally raise linagliptin levels. Given linagliptin's wide safety margin, a clinically relevant effect is unlikely.
What this interaction means in plain words
Empagliflozin-linagliptin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-linagliptin belongs to Endocrine; Sarecycline belongs to Anti Bacterial.
Why it happens
Weak inhibition of P-glycoprotein efflux of linagliptin.
What to do
No dose adjustment is needed; routine glucose monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Empagliflozin-linagliptin with Sarecycline?
MediHelp rates the interaction as minor. Empagliflozin-linagliptin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a weak P-gp inhibitor and could marginally raise linagliptin levels. Given linagliptin's wide safety margin, a clinically relevant effect is unlikely.
How serious is the interaction between Empagliflozin-linagliptin and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; routine glucose monitoring is sufficient.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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