Drug interactions
Empagliflozin-linagliptin + Tolbutamide
Severity: Moderate
Empagliflozin-linagliptin and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding empagliflozin and linagliptin to a sulfonylurea increases the risk of hypoglycemia. The risk is greatest in older patients and those with renal impairment or poor intake.
What this interaction means in plain words
Empagliflozin-linagliptin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-linagliptin belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects, with sulfonylurea-driven insulin secretion enhanced by incretin effects.
What to do
Consider reducing the tolbutamide dose when starting the combination. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Empagliflozin-linagliptin and Tolbutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Empagliflozin-linagliptin
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Empagliflozin-linagliptin with Tolbutamide?
MediHelp rates the interaction as moderate. Empagliflozin-linagliptin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding empagliflozin and linagliptin to a sulfonylurea increases the risk of hypoglycemia. The risk is greatest in older patients and those with renal impairment or poor intake.
How serious is the interaction between Empagliflozin-linagliptin and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolbutamide dose when starting the combination. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
