Drug interactions
Empagliflozin-metformin + Fosinopril
Severity: Moderate
Empagliflozin-metformin and Fosinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Renal impairment or volume depletion from either drug class may also raise the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Empagliflozin-metformin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Fosinopril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity, and any ACE inhibitor-related fall in renal function can reduce metformin clearance.
What to do
Monitor blood glucose and renal function, especially after initiation or dose changes. Hold metformin if renal function deteriorates significantly or in acute volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Frequently asked questions
Can I take Empagliflozin-metformin with Fosinopril?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Fosinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Renal impairment or volume depletion from either drug class may also raise the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Empagliflozin-metformin and Fosinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, especially after initiation or dose changes. Hold metformin if renal function deteriorates significantly or in acute volume depletion.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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