Drug interactions
Empagliflozin-metformin + Givinostat
Severity: Minor
Empagliflozin-metformin and Givinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak inhibitor of transporters involved in metformin renal clearance. Metformin exposure may rise slightly, which matters mainly in patients with reduced renal function because of lactic acidosis risk.
What this interaction means in plain words
Empagliflozin-metformin and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Givinostat belongs to Miscellaneous.
Why it happens
Inhibition of renal organic cation transport may reduce metformin elimination.
What to do
Monitor renal function and for signs of metformin toxicity such as gastrointestinal upset. Consider lowering the metformin dose if renal impairment is present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Empagliflozin-metformin with Givinostat?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak inhibitor of transporters involved in metformin renal clearance. Metformin exposure may rise slightly, which matters mainly in patients with reduced renal function because of lactic acidosis risk.
How serious is the interaction between Empagliflozin-metformin and Givinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin toxicity such as gastrointestinal upset. Consider lowering the metformin dose if renal impairment is present.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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