Drug interactions
Empagliflozin-metformin + Lisinopril
Severity: Moderate
Empagliflozin-metformin and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can modestly improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They can also reduce renal function in volume-depleted patients, which, together with the diuretic effect of empagliflozin, may raise metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Empagliflozin-metformin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
Additive blood pressure and volume effects with possible renal function decline that reduces metformin clearance; ACE inhibitors may also enhance insulin sensitivity.
What to do
Monitor renal function, potassium, volume status, and glucose after starting or adjusting therapy. Hold metformin if acute kidney injury or dehydration occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Empagliflozin-metformin with Lisinopril?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can modestly improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They can also reduce renal function in volume-depleted patients, which, together with the diuretic effect of empagliflozin, may raise metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Empagliflozin-metformin and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium, volume status, and glucose after starting or adjusting therapy. Hold metformin if acute kidney injury or dehydration occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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