Drug interactions
Empagliflozin-metformin + Mecasermin
Severity: Moderate
Empagliflozin-metformin and Mecasermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin (recombinant IGF-1) has insulin-like activity and commonly causes hypoglycemia. Combined with antidiabetic agents, glucose lowering may be enhanced, although metformin and empagliflozin carry low intrinsic hypoglycemia risk.
What this interaction means in plain words
Empagliflozin-metformin and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Mecasermin belongs to Endocrine.
Why it happens
IGF-1 activates insulin receptors and increases peripheral glucose uptake, adding to antidiabetic effects.
What to do
Give mecasermin with or shortly after a meal and monitor blood glucose closely. Reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Mecasermin
Frequently asked questions
Can I take Empagliflozin-metformin with Mecasermin?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin (recombinant IGF-1) has insulin-like activity and commonly causes hypoglycemia. Combined with antidiabetic agents, glucose lowering may be enhanced, although metformin and empagliflozin carry low intrinsic hypoglycemia risk.
How serious is the interaction between Empagliflozin-metformin and Mecasermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give mecasermin with or shortly after a meal and monitor blood glucose closely. Reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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