Drug interactions
Empagliflozin-metformin + Nateglinide
Severity: Moderate
Empagliflozin-metformin and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SGLT2 inhibitor with an insulin secretagogue such as nateglinide may increase hypoglycemia risk. The risk is lower than with sulfonylureas because nateglinide acts briefly, but it is still present.
What this interaction means in plain words
Empagliflozin-metformin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive glucose lowering from meal-related insulin secretion by nateglinide and urinary glucose excretion by empagliflozin.
What to do
Consider reducing the nateglinide dose when starting empagliflozin and advise the patient to monitor blood glucose and recognize hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Empagliflozin-metformin with Nateglinide?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SGLT2 inhibitor with an insulin secretagogue such as nateglinide may increase hypoglycemia risk. The risk is lower than with sulfonylureas because nateglinide acts briefly, but it is still present.
How serious is the interaction between Empagliflozin-metformin and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the nateglinide dose when starting empagliflozin and advise the patient to monitor blood glucose and recognize hypoglycemia symptoms.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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