Drug interactions
Empagliflozin-metformin + Nilotinib
Severity: Moderate
Empagliflozin-metformin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib commonly causes hyperglycemia and can worsen glycemic control in diabetic patients. Glucose-lowering therapy may need intensification.
What this interaction means in plain words
Empagliflozin-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Nilotinib is associated with hyperglycemia through incompletely defined effects on glucose metabolism, opposing antidiabetic drugs pharmacodynamically.
What to do
Monitor blood glucose regularly during nilotinib therapy and adjust antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Nilotinib?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib commonly causes hyperglycemia and can worsen glycemic control in diabetic patients. Glucose-lowering therapy may need intensification.
How serious is the interaction between Empagliflozin-metformin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during nilotinib therapy and adjust antidiabetic treatment as needed.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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