Drug interactions
Empagliflozin-metformin + Pasireotide
Severity: Major
Empagliflozin-metformin and Pasireotide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide frequently causes hyperglycemia and can lead to diabetes. It can therefore counteract the glucose-lowering effect of empagliflozin-metformin.
What this interaction means in plain words
Empagliflozin-metformin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Empagliflozin-metformin belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Pasireotide suppresses insulin and incretin (GLP-1, GIP) secretion, opposing antidiabetic therapy.
What to do
Monitor glucose before and during pasireotide therapy and intensify antidiabetic treatment as needed. Consider incretin-based agents if control is inadequate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Empagliflozin-metformin
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Empagliflozin-metformin with Pasireotide?
MediHelp rates the interaction as major. Empagliflozin-metformin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pasireotide frequently causes hyperglycemia and can lead to diabetes. It can therefore counteract the glucose-lowering effect of empagliflozin-metformin.
How serious is the interaction between Empagliflozin-metformin and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose before and during pasireotide therapy and intensify antidiabetic treatment as needed. Consider incretin-based agents if control is inadequate.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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