Drug interactions
Empagliflozin-metformin + Phenelzine
Severity: Moderate
Empagliflozin-metformin and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective MAO inhibitors such as phenelzine can lower blood glucose and may enhance the effect of antidiabetic drugs. When combined with metformin and empagliflozin, glucose-lowering may be greater than expected.
What this interaction means in plain words
Empagliflozin-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic glucose lowering from MAO inhibition, which can enhance insulin sensitivity and alter glucose regulation; not a defined pharmacokinetic interaction.
What to do
Monitor blood glucose when phenelzine is started or stopped and adjust antidiabetic doses if glucose falls or rises. Teach the patient to recognize hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Empagliflozin-metformin with Phenelzine?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective MAO inhibitors such as phenelzine can lower blood glucose and may enhance the effect of antidiabetic drugs. When combined with metformin and empagliflozin, glucose-lowering may be greater than expected.
How serious is the interaction between Empagliflozin-metformin and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when phenelzine is started or stopped and adjust antidiabetic doses if glucose falls or rises. Teach the patient to recognize hypoglycemia symptoms.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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