Drug interactions
Empagliflozin-metformin + Promethazine
Severity: Minor
Empagliflozin-metformin and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine, a phenothiazine antihistamine, may raise blood glucose and reduce glycemic control in patients taking metformin and empagliflozin. Clinical effects are usually small with short courses.
What this interaction means in plain words
Empagliflozin-metformin and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin-metformin belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Phenothiazine-class effects on glucose tolerance and insulin secretion may oppose antidiabetic action.
What to do
Monitor blood glucose if promethazine is used for prolonged periods. Adjust antidiabetic therapy only if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Empagliflozin-metformin with Promethazine?
MediHelp rates the interaction as minor. Empagliflozin-metformin and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine, a phenothiazine antihistamine, may raise blood glucose and reduce glycemic control in patients taking metformin and empagliflozin. Clinical effects are usually small with short courses.
How serious is the interaction between Empagliflozin-metformin and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if promethazine is used for prolonged periods. Adjust antidiabetic therapy only if control deteriorates.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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