Drug interactions
Empagliflozin-metformin + Trandolapril
Severity: Moderate
Empagliflozin-metformin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia with antidiabetic drugs. With empagliflozin they can also contribute to volume depletion and renal function decline, raising metformin accumulation risk.
What this interaction means in plain words
Empagliflozin-metformin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Additive glucose lowering through improved insulin sensitivity, plus combined hemodynamic effects on renal function.
What to do
Monitor glucose, blood pressure, volume status and renal function after initiation or dose changes. Hold during acute dehydrating illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Empagliflozin-metformin with Trandolapril?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia with antidiabetic drugs. With empagliflozin they can also contribute to volume depletion and renal function decline, raising metformin accumulation risk.
How serious is the interaction between Empagliflozin-metformin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, blood pressure, volume status and renal function after initiation or dose changes. Hold during acute dehydrating illness.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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