Drug interactions
Empagliflozin-metformin + Triamterene
Severity: Moderate
Empagliflozin-metformin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin adds osmotic diuresis to triamterene's diuretic effect, increasing the chance of volume depletion, hypotension and kidney injury. Triamterene can also compete with metformin for renal secretion.
What this interaction means in plain words
Empagliflozin-metformin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin-metformin belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Additive diuretic effects, and triamterene inhibits renal organic cation transport that clears metformin.
What to do
Monitor volume status, blood pressure, potassium and renal function, and lower the diuretic dose if depletion occurs. Monitor for metformin adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Empagliflozin-metformin with Triamterene?
MediHelp rates the interaction as moderate. Empagliflozin-metformin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin adds osmotic diuresis to triamterene's diuretic effect, increasing the chance of volume depletion, hypotension and kidney injury. Triamterene can also compete with metformin for renal secretion.
How serious is the interaction between Empagliflozin-metformin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor volume status, blood pressure, potassium and renal function, and lower the diuretic dose if depletion occurs. Monitor for metformin adverse effects.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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