Drug interactions
Emtricitabine + Fenoprofen
Severity: Moderate
Emtricitabine and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Emtricitabine is eliminated by glomerular filtration and tubular secretion, and NSAIDs may reduce renal function. High or multiple doses of NSAIDs can therefore increase emtricitabine exposure and renal adverse effects.
What this interaction means in plain words
Emtricitabine and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID-related reduction in renal perfusion and possible competition for tubular secretion decreases emtricitabine clearance.
What to do
Prefer a non-NSAID analgesic where possible, and monitor renal function if prolonged NSAID use is needed, especially when emtricitabine is combined with tenofovir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Fenoprofen?
MediHelp rates the interaction as moderate. Emtricitabine and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Emtricitabine is eliminated by glomerular filtration and tubular secretion, and NSAIDs may reduce renal function. High or multiple doses of NSAIDs can therefore increase emtricitabine exposure and renal adverse effects.
How serious is the interaction between Emtricitabine and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic where possible, and monitor renal function if prolonged NSAID use is needed, especially when emtricitabine is combined with tenofovir.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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