Drug interactions
Emtricitabine + Ketorolac
Severity: Moderate
Emtricitabine and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can reduce renal function, which may raise emtricitabine exposure. Ketorolac is also nephrotoxic, so renal risk is amplified, particularly with repeated dosing.
What this interaction means in plain words
Emtricitabine and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Emtricitabine belongs to Anti Virals; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal function and possible competition for tubular secretion may reduce emtricitabine clearance.
What to do
Prefer a non-NSAID analgesic; if ketorolac is needed, keep the course short and monitor serum creatinine and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Emtricitabine with Ketorolac?
MediHelp rates the interaction as moderate. Emtricitabine and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Emtricitabine is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can reduce renal function, which may raise emtricitabine exposure. Ketorolac is also nephrotoxic, so renal risk is amplified, particularly with repeated dosing.
How serious is the interaction between Emtricitabine and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic; if ketorolac is needed, keep the course short and monitor serum creatinine and renal function.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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