Drug interactions
Enalapril + Leniolisib
Severity: Moderate
Enalapril and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3 and may raise exposure to substrates of these transporters. Enalapril is a prodrug whose hepatic uptake and activation may be affected, so the clinical consequence is uncertain and likely modest.
What this interaction means in plain words
Enalapril and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Leniolisib belongs to Miscellaneous.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake transporters by leniolisib may alter enalapril disposition.
What to do
Monitor blood pressure and renal function when starting or stopping leniolisib. Adjust the enalapril dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Enalapril with Leniolisib?
MediHelp rates the interaction as moderate. Enalapril and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3 and may raise exposure to substrates of these transporters. Enalapril is a prodrug whose hepatic uptake and activation may be affected, so the clinical consequence is uncertain and likely modest.
How serious is the interaction between Enalapril and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when starting or stopping leniolisib. Adjust the enalapril dose according to response.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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