Drug interactions
Enalapril + Linagliptin-metformin
Severity: Minor
Enalapril and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally lead to hypoglycemia in patients on antidiabetic drugs. Enalapril may also reduce renal function in susceptible patients, which could raise metformin accumulation and lactic acidosis risk.
What this interaction means in plain words
Enalapril and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
ACE inhibition may improve insulin sensitivity, and renal function decline may reduce metformin clearance.
What to do
Monitor blood glucose and renal function periodically, particularly after starting or changing ACE inhibitor dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Linagliptin-metformin?
MediHelp rates the interaction as minor. Enalapril and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can enhance insulin sensitivity and occasionally lead to hypoglycemia in patients on antidiabetic drugs. Enalapril may also reduce renal function in susceptible patients, which could raise metformin accumulation and lactic acidosis risk.
How serious is the interaction between Enalapril and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function periodically, particularly after starting or changing ACE inhibitor dose.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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