Drug interactions
Enalapril + Saxagliptin-metformin
Severity: Moderate
Enalapril and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors like enalapril may increase insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. DPP-4 inhibitors also carry a small additive angioedema risk with ACE inhibitors. Renal impairment from ACE inhibitors may raise metformin accumulation risk.
What this interaction means in plain words
Enalapril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Improved insulin sensitivity and bradykinin accumulation; reduced renal function may impair metformin clearance.
What to do
Monitor glucose and renal function after starting enalapril. Counsel patients to report facial or tongue swelling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Frequently asked questions
Can I take Enalapril with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Enalapril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors like enalapril may increase insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. DPP-4 inhibitors also carry a small additive angioedema risk with ACE inhibitors. Renal impairment from ACE inhibitors may raise metformin accumulation risk.
How serious is the interaction between Enalapril and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function after starting enalapril. Counsel patients to report facial or tongue swelling.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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