Drug interactions
Enalapril-hydrochlorothiazide + Fenbufen
Severity: Moderate
Enalapril-hydrochlorothiazide and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen is an NSAID, and NSAIDs can reduce the antihypertensive and diuretic effects of ACE inhibitors and thiazides. In patients who are volume depleted or elderly, the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, renal function and potassium, ensure adequate hydration, and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Fenbufen?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen is an NSAID, and NSAIDs can reduce the antihypertensive and diuretic effects of ACE inhibitors and thiazides. In patients who are volume depleted or elderly, the combination also raises the risk of acute kidney injury.
How serious is the interaction between Enalapril-hydrochlorothiazide and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium, ensure adequate hydration, and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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