Drug interactions
Enalapril-hydrochlorothiazide + Fentanyl
Severity: Moderate
Enalapril-hydrochlorothiazide and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may cause hypotension and can induce antidiuretic hormone release, which may blunt diuretic effect and cause fluid retention. Together with an ACE inhibitor and thiazide, hypotension may be more pronounced, particularly during anesthesia or after dose increases.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Fentanyl belongs to Musculoskeletal.
Why it happens
Opioid-induced histamine release and vasodilation add to antihypertensive effect, while ADH release may counteract diuresis.
What to do
Monitor blood pressure, fluid status and urine output during fentanyl use. Adjust the antihypertensive or diuretic dose if hypotension or fluid retention occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Fentanyl?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids may cause hypotension and can induce antidiuretic hormone release, which may blunt diuretic effect and cause fluid retention. Together with an ACE inhibitor and thiazide, hypotension may be more pronounced, particularly during anesthesia or after dose increases.
How serious is the interaction between Enalapril-hydrochlorothiazide and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and urine output during fentanyl use. Adjust the antihypertensive or diuretic dose if hypotension or fluid retention occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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