Drug interactions
Enalapril-hydrochlorothiazide + Formoterol
Severity: Moderate
Enalapril-hydrochlorothiazide and Formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium through beta-2 stimulation, and with hydrochlorothiazide this may cause clinically significant hypokalemia, increasing the risk of arrhythmias, particularly in hypoxic patients.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Formoterol belongs to Respiratory.
Why it happens
Beta-2 agonist cellular potassium shift added to thiazide renal potassium loss.
What to do
Monitor serum potassium, especially with high formoterol doses or in acute asthma or COPD exacerbation, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Formoterol?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol can lower serum potassium through beta-2 stimulation, and with hydrochlorothiazide this may cause clinically significant hypokalemia, increasing the risk of arrhythmias, particularly in hypoxic patients.
How serious is the interaction between Enalapril-hydrochlorothiazide and Formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with high formoterol doses or in acute asthma or COPD exacerbation, and replace potassium as needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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