Drug interactions
Enalapril-hydrochlorothiazide + Ganciclovir
Severity: Minor
Enalapril-hydrochlorothiazide and Ganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganciclovir is renally eliminated, partly by active tubular secretion. Hydrochlorothiazide may slightly reduce its clearance, and diuretic-induced volume depletion or reduced renal function could further increase exposure. Higher ganciclovir levels raise the risk of myelosuppression and other toxicity.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Ganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion and reduced renal perfusion, decreasing ganciclovir clearance.
What to do
Dose ganciclovir according to creatinine clearance and monitor renal function and blood counts during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Ganciclovir?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ganciclovir is renally eliminated, partly by active tubular secretion. Hydrochlorothiazide may slightly reduce its clearance, and diuretic-induced volume depletion or reduced renal function could further increase exposure. Higher ganciclovir levels raise the risk of myelosuppression and other toxicity.
How serious is the interaction between Enalapril-hydrochlorothiazide and Ganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose ganciclovir according to creatinine clearance and monitor renal function and blood counts during therapy.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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