Drug interactions
Enalapril-hydrochlorothiazide + Glecaprevir / pibrentasvir
Severity: Minor
Enalapril-hydrochlorothiazide and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit OATP1B1/1B3 and may increase exposure to enalapril, a substrate of hepatic uptake and prodrug conversion pathways. The clinical significance is likely small, but exaggerated blood pressure lowering is possible.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of OATP1B1/1B3 transporters by glecaprevir/pibrentasvir, possibly raising enalapril concentrations.
What to do
No routine dose change is needed; monitor blood pressure and renal function when starting the antiviral course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Enalapril-hydrochlorothiazide and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit OATP1B1/1B3 and may increase exposure to enalapril, a substrate of hepatic uptake and prodrug conversion pathways. The clinical significance is likely small, but exaggerated blood pressure lowering is possible.
How serious is the interaction between Enalapril-hydrochlorothiazide and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood pressure and renal function when starting the antiviral course.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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