Drug interactions
Enalapril-hydrochlorothiazide + Glibenclamide
Severity: Moderate
Enalapril-hydrochlorothiazide and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance the glucose-lowering effect of sulfonylureas and occasionally precipitate hypoglycemia. The thiazide component can raise glucose and partly counteract this, so glycemic control may change in either direction.
What this interaction means in plain words
Enalapril-hydrochlorothiazide and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enalapril-hydrochlorothiazide belongs to Cardiovascular; Glibenclamide belongs to Endocrine.
Why it happens
ACE inhibition may increase insulin sensitivity, while thiazides may reduce glucose tolerance.
What to do
Monitor blood glucose when starting, stopping or adjusting the combination. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Enalapril-hydrochlorothiazide with Glibenclamide?
MediHelp rates the interaction as moderate. Enalapril-hydrochlorothiazide and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance the glucose-lowering effect of sulfonylureas and occasionally precipitate hypoglycemia. The thiazide component can raise glucose and partly counteract this, so glycemic control may change in either direction.
How serious is the interaction between Enalapril-hydrochlorothiazide and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or adjusting the combination. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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